Pioneering A More Enlightened Approach to Treating Depression with BeBright

Updated: 2 days ago

A recent review of multiple research studies carried out over the years has concluded that SSRIs, anti-depression medications which aim to increase serotonin levels, are depressingly ineffective. Low serotonin levels are not the key driver of depression.


Expert Dr Jonathan Raskin from State University of New York said that many psychiatrists KNEW that the theory upon which SSRIs was built on was 'incomplete'.


Scott Stossel writes in his book My Age of Anxiety: Fear, Hope, Dread, and the Search for Peace of Mind that after reviewing dozens of studies on SSRI efficacy, The British Medical Journal (The BMJ) concluded that drugs in the SSRI class "do not have a clinically meaningful advantage over a placebo."


Interestingly, if you look at the overall stats for the incidence of depression since SSRIs medications came into being, they have not decreased rates of depression, in fact, quite the reverse:



Antidepressants have been proven to be largely ineffective
A recent review of multiple research studies carried out over the years has concluded that SSRIs, anti-depression medications which aim to increase serotonin levels, are depressingly ineffective.

BeBright, The Key Clinic's sister company which focuses on intelligent healthcare for adults, is pioneering a game-changing, drug-free treatment approach to build mental health resilience of employees within companies, based on the work of The Walsh Institute in the US.


At a time when we are facing a global mental health crisis, with 1 in every 4 adults saying they have experienced depression or anxiety over the last year, the world needs a new, more intelligent approach.


The recent findings regarding the ineffectiveness of SSRIs come as no surprise to BeBright. The Walsh Institute (a not-for profit organisation based in the US) has spent the last 30 years analysing the complex differences in biochemistry underlying mental illness. Having compiled the biggest biochemical database anywhere in the world, their findings reveal that, contrary to the existing, simplistic serotonin theory of depression, there are, in fact, five completely different types of depression, each requiring a different treatment approach:


1. Low serotonin levels only account for 38% of the depressed population - known as ‘undermethylators’. This explains the research results: the efficacy of drugs which increase serotonin only work for about 40% of the population (about the same level as a sugar pill). Two massive studies from 2006 showed that patients do not get better taking antidepressants; only about a third improved dramatically after the first trial (again, directly mirroring Walsh’s quantification of ‘undermethylators’).


2. However, another 20% of those with depression actually have the opposite problem - they have too much serotonin and norepinephrine - ‘overmethylators’. If you give SSRIs to this group of people, you make the problem worse and they can and do become suicidally depressed. And yet, this has been the standard medical practice to treating mental health problems over many years - ‘prescribe and see’ without ANY form of testing first to identify an individual’s specific biochemical depression type.


3. Postnatal Depression sits in a separate category again and is caused by an excess of copper build up, which occurs during pregnancy. Most people are able to detoxify this build up after giving birth, but those who develop Posnatal Depression cannot, leading to extreme anxiety and even, in its more extreme form, psychosis. While SSRIs wont make things worse, they do little to help treat the underlying problem.


Two further types of depression are caused by:


4) An underlying pyrrole disorder - an inherited inability to maintain sufficient levels of vitamin B6 and Zinc in the body, causing neurotransmitter imbalances and high levels of oxidative stress.


And lastly,


5) A build up of toxins, when the body’s natural ability to detoxify is compromised, again, disrupting neurotransmitter levels.


BeBright's method of treatment is to test first to accurately diagnose the specific type of depression and then to treat by providing the body with what it needs to rectify the problem itself, using highly targeted nutrients. The efficacy rates of this break-through new approach speak for themselves - 70-90% efficacy, without the debilitating side effects and dependency issues which can come from medicating.


What is interesting is that oxidative stress and likely resulting brain inflammation appears to be a factor across all types of mental illness, again, something which has been largely ignored to date.


There is a brighter way to go about mental healthcare, without the endless dependency on medication to squash symptoms. We need to begin by accepting that the brain and body function as one and that mental and physical health are inextricably linked and should be treated together.


More coming soon on BeBright's intelligent approach to healthcare.




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